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The degree of substitution refers to the average number of hydroxyethyl groups attached to the cellulose backbone. This parameter significantly affects the polymer's hydrophilicity and solubility. HEC with a higher degree of substitution displays increased solubility in water due to the greater number of hydroxyl groups available for hydrogen bonding with water molecules. Consequently, formulators often choose HEC grades with varying degrees of substitution based on the desired viscosity and solubility characteristics for specific applications.
hydroxyethyl cellulose solubility
