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    In its 2016 opinion, the ANS Panel recommended new studies be carried out to fill the gaps on possible effects on the reproductive system, which could enable them to set an Acceptable Daily Intake (ADI ). Uncertainty around the characterisation of the material used as the food additive (E 171) was also highlighted, in particular with respect to particle size and particle size distribution of titanium dioxide used as E 171.   

    The production of titanium dioxide powder has significant environmental impacts, primarily due to the energy-intensive nature of the chloride processcas: 13463-67-7 titanium dioxide powder factory. However, manufacturers are increasingly adopting more sustainable practices to minimize their environmental footprint. For instance, they are exploring alternative production methods such as the sulfate process, which uses sulfuric acid instead of chlorine gas, resulting in lower greenhouse gas emissions.