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    The Enchantment of a Tin Candy Box FactoryIn a quaint little town, nestled between rolling hills and vibrant meadows, stands a charming establishment known as the Tin Candy Box Factory. The factory, with its rustic brick walls and colorful tin roofs, resembles a page from a fairy tale. From the moment you step inside, you are transported into a world of whimsy and delight, where the air is filled with the sweet aroma of caramel, chocolate, and a medley of fruity flavors.The factory is renowned for its exquisite, handmade candies packed in beautifully designed tin boxes. Each box tells a story, from the vintage floral patterns to whimsical cartoon characters that enchant both young and old. The skilled artisans at the factory pour their hearts into every creation, crafting candies that not only please the palate but also captivate the eyes. The art of tin box making is a tradition that has been handed down through generations, blending meticulous craftsmanship with modern design.As visitors wander through the factory, they are greeted by the rhythmic sounds of chocolate being tempered and the soft whispers of confectioners discussing their latest creations. The factory offers guided tours, allowing guests to witness the magic that unfolds daily. Children giggle with delight as they observe the candy-making process—hot sugar being spun into delicate shards, vibrant lollipops being crafted, and chocolates being hand-painted with edible colors.One of the factory's most popular experiences is the “Candy Creation Workshop,” where visitors can unleash their creativity. Here, participants can choose their favorite flavors and colors to create their own unique candy blends. The workshop nurtures a sense of joy and connection, as families and friends bond over their shared love for sweets. The factory also hosts seasonal events, such as Candy Wonderland during the winter holidays, where the entire establishment is transformed into a festive haven filled with dazzling lights and holiday-themed treats.The story of the Tin Candy Box Factory is not just about candy; it is also about the community that supports it. Local farmers supply fresh ingredients, ensuring that all candies are made with the finest quality. The factory collaborates with regional artists to create limited edition tin designs, fostering a deeper connection with the local culture and heritage. Each purchase supports not only the factory but also the livelihoods of countless individuals in the community.As you leave the Tin Candy Box Factory, a sense of nostalgia washes over you. The memories of tasting delightful flavors and admiring the intricate tin boxes linger long after you’ve departed. The factory is not merely a place of production; it is a treasure trove of creativity, tradition, and community spirit. It celebrates the simple joy of candy and the unique stories that accompany each tin box. In our fast-paced world, it reminds us of the beauty found in craftsmanship, the joy of sharing, and the sweetness of life itself. Whether you are a local or a traveler passing through, the Tin Candy Box Factory is a destination that promises to delight and inspire.


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    The skin of an adult person is, in most places, covered with a relatively thick (∼10 μm) barrier of keratinised dead cells. One of the main questions is still whether TiO2 NPs are able to penetrate into the deeper layers of the skin. The majority of studies suggest that TiO2 NPs, neither uncoated nor coated (SiO2, Al2O3 and SiO2/Al2O3) of different crystalline structures, penetrate normal animal or human skin. However, in most of these studies the exposures were short term (up to 48 h); only few long-term or repeated exposure studies have been published. Wu et al.83 have shown that dermal application of nano-TiO2 of different crystal structures and sizes (4–90 nm) to pig ears for 30 days did not result in penetration of NPs beyond deep epidermis. On the other hand, in the same study the authors reported dermal penetration of TiO2 NPs with subsequent appearance of lesions in multiple organs in hairless mice, that were dermal exposed to nano-TiO2 for 60 days. However, the relevance of this study for human exposure is not conclusive because hairless mice skin has abnormal hair follicles, and mice stratum corneum has higher lipid content than human stratum corneum, which may contribute to different penetration. Recently Sadrieh et al. performed a 4 week dermal exposure to three different TiO2 particles (uncoated submicron-sized, uncoated nano-sized and coated nano-sized) in 5 % sunscreen formulation with minipigs. They found elevated titanium levels in epidermis, dermis and in inguinal lymph nodes, but not in precapsular and submandibular lymph nodes and in liver. With the energy dispersive X-ray spectrometry and transmission electron microscopy (TEM) analysis the authors confirmed presence of few TiO2 particles in dermis and calculated that uncoated nano-sized TiO2 particles observed in dermis represented only 0.00008 % of the total applied amount of TiO2 particles. Based on the same assumptions used by the authors in their calculations it can be calculated that the total number of particles applied was 1.8 × 1013 /cm2 and of these 1.4 x107/cm2 penetrated. The surface area of skin in humans is around 1.8 m2  and for sun protection the cream is applied over whole body, which would mean that 4 week usage of such cream with 5 % TiO2 would result in penetration of totally 2.6 × 1010 particles. Although Sadrieh et al.concluded that there was no significant penetration of TiO2 NPs through intact normal epidermis, the results are not completely confirmative.