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Is it safe?: In an FDA study with rats, there were no significant toxic effects other than growth retardation once HPMC reached levels of 20 to 30% of the rats’ diet. This study noted that growth retardation may be contributed to malnutrition and not the amount of HPMC. In another study, rabbits were injected with 2% HPMC for over a month and there were no observations of toxicity or irritation. Overall, the FDA sees it as a non-toxic and non-irritating inactive ingredient that is safe for human use and consumption.
The degree of substitution (DS) of HEC, which indicates how many hydroxyl groups have been replaced by hydroxyethyl groups, can be controlled during production to tailor the properties of the final product. Higher DS values generally lead to increased solubility and viscosity. After the reaction, the HEC is purified and dried to produce a fine white powder that is easily reconstituted in water.
hec cellulose
