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The degree of substitution (DS) is another vital parameter used to categorize HPMC grades. It refers to the average number of hydroxyl groups in the cellulose molecule that are replaced by hydroxypropyl and methyl groups. A higher DS generally correlates with increased hydrophobicity and a reduction in solubility in cold water. Therefore, formulations requiring faster solubility may leverage lower DS grades, while those needing delayed release or thicker consistency might benefit from higher DS grades.
grades of hpmc
