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2. Ethanol Concentration The concentration of ethanol plays a crucial role in HPMC solubility. Pure ethanol is generally considered a poor solvent for HPMC, leading to incomplete dissolution. However, mixtures of ethanol and water can enhance solubility. Typically, a mixture with a ratio of 6040 (ethanol to water) has been shown to optimize the solubility of HPMC, achieving a balance between solvent interaction and dissolution efficiency.
hpmc solubility in ethanol
