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The methylation process involves the substitution of hydroxyl (-OH) groups on the cellulose chain with methyl (-OCH₃) groups, which enhances the hydrophobic characteristics of the polymer. This substitution plays a critical role in determining the solubility and viscosity of HPMC in various solvents. The degree of substitution, which refers to the average number of hydroxyl groups replaced by methyl groups, greatly influences the properties of HPMC, such as its thickening ability and gel formation capacity.
chemical structure of hpmc
